Gravimetric Dilution: More Accurate than Volumetric. Eliminate temperature-dependent errors and achieve precision in every preparation.
Solutions prepared using volumetric glassware are inherently inaccurate because of the density change of the solvent as the laboratory changes temperature. The magnitude of this error can be understood by referring to Table 1. Since Borosilicate (Pyrex) glassware changes volume by only 0.013% over the same temperature span, the errors caused by this volumetric change can easily be as high as 0.5%.
Modern analytical instruments can routinely measure to an accuracy much better than 0.5%; however, in order to reach this potential, the solutions used in these techniques must be prepared to an accuracy three to ten times better (0.16% to 0.05%).
Change in Solvent Density as Temperature Increases by 5 degrees C
| Solvent | % Decrease in Density |
|---|---|
| Acetone | 0.758% |
| Acetic Acid | 0.510% |
| Methanol | 0.827% |
| Ethanol | 0.825% |
| n-Propanol | 0.503% |
| Methyl Ethyl Ketone | 0.658% |
| Toluene | 0.616% |
| Benzene | 0.687% |
| Carbon Tetrachloride | 0.401% |
| Chloroform | 0.422% |
| Methylene Chloride | 0.513% |
| Water | 0.116% |
| Cyclohexane | 0.706% |
| Dimethyl Sulfoxide | 0.497% |
Note: Borosilicate (Pyrex) glassware changes volume by only 0.013% over the same temperature span.
What are the costs of solvent mixing and solution preparation using the volumetric method vs the gravimetric method (PhasePrep)?
With PhasePrep, the cost of purchasing, replacing, and cleaning volumetric glassware is replaced by the cost of uncalibrated solvent containers. No need for expensive calibrated volumetric flasks.
With PhasePrep, 135 ml or 653 ml of a solution can be prepared as easily as one liter. Solvent waste is minimized because you prepare exactly what you need.
PhasePrep is a closed system. The exposure to spilled solvents, broken glassware, and harmful solvent vapors is reduced dramatically.
This is the highest cost of all. What price can be put on mis-identifying a peak in a chromatogram because the solvent was not mixed accurately or a mislabeled solvent was used? PhasePrep prepares mixtures to an accuracy of a few hundredths of one percent or better - every time. A label is also printed to document the preparation.
PhasePrep prepares mixtures to an accuracy of a few hundredths of one percent or better - every time. This level of precision ensures:
Schedule a demonstration and see how gravimetric preparation can transform your laboratory workflow.
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