Mixed-mode separation media for liquid chromatography. Innovative column technologies designed for complex separations that traditional columns can't achieve.
Each product line offers unique selectivity and separation capabilities for different analytical challenges.
Mixed-Mode HPLC Columns
Specifically designed for mixed-mode separations, capable of separating a tremendous range of compounds by different separation modes based only upon mobile phase selection.
Universal Separation Platform
A new generation of separation media offering a universal platform for all types of small molecule separation. Overcomes limitations of previous mixed-mode media.
Liquid Separation Cell Technology
The latest innovative columns with LiSC™ technology. Obelisc R (reversed-phase) and Obelisc N (normal-phase) separate polar and non-polar compounds using multiple mechanisms.
USP-Compliant Single-Mode Columns
USP-qualified columns meeting L1, L3, L8, and L16 designations. Includes C18 reverse-phase, bare silica normal-phase, aminopropylsilane, and C12 columns for standard chromatographic applications.
Cannabis & Cannabinoid Analysis
Reverse-phase analytical columns specifically designed for cannabinoid separation. Retains neutral cannabinoids through reverse-phase mechanism with specialized handling of acidic cannabinoids like THCA and CBDA.
Hydrogen-bond Adsorption Resolution
SHARC™ columns are the first commercially available columns that primarily utilize separation based on hydrogen bonding. Specific Hydrogen-bond Adsorption Resolution Chromatography for unique selectivity.
Adaptive Mixed-Mode Separation
An expanding product line featuring adaptive mixed-mode chromatography columns designed for versatile separation applications. OMNI columns provide flexible selectivity for a wide range of analytes.
Application-Specific Solutions
Specialized columns for unique applications including oligonucleotide analysis (OligoMg), polyethyleneimine (PEI), lipidomics (Lipak), protein/peptide analysis (Promix MP), and polymer analysis (PVP).
Select the correct column by their functional group acidity to match the pKa value of your basic compounds.
Columns with negatively charged functional groups due to the embedded anionic ion-pairing reagent.
Primesep A - Strongest acidic phase
Primesep 100 - Strong acidic phase
Primesep 200 - Medium acidic phase
MOREColumns with positively charged functional groups.
Primesep B - Strong basic column for use with TFA, phosphoric or perchloric acid solutions.
Primesep B2 - Weak basic column for ammonium acetate buffered solution.
MOREColumn with unique unparalleled selectivity.
Primesep C - Combined reverse-phase and complex formation properties for interaction with amines, sulfonium, phosphonium and metal ions.
MOREThree interactions within one column:
Primesep P - For separation of structural isomers of aromatic compounds.
MORETwo Obelisc columns with unique liquid separation cell properties for comprehensive compound separation.
Obelisc R has cationic groups close to the silica surface separated from anionic groups by a hydrophobic chain. Features reversed-phase characteristics.
Obelisc N has anions close to the surface separated from cationic groups by a hydrophilic chain. Features normal-phase characteristics.
Our technical experts can help you choose the best SIELC column for your specific application.
