What are the costs of solvent mixing and solution preparation using the volumetric method vs the gravimetric method (PhasePrep II)?

• Safety is improved because the pouring and spillage associated with the volumetric method is reduced dramatically or eliminated.
• The gravimetric method is inherently more accurate than the volumetric method because the temperature of the solvent can be ignored. The amount of solvent contained by a volumetric flask is a function of temperature—but the weight of the solvent is not affected by temperature.

What are the costs of solvent mixing and solution preparation using the volumetric method vs the gravimetric method (PhasePrep II)?

• The cost of purchasing, replacing and cleaning of volumetric glassware. With the PhasePrep II this is replaced by the cost of uncalibrated solvent containers.
• The cost of wasted solvent. With the PhasePrep II, 135 ml or 653 ml of a solution can be prepared as easily as one liter. Solvent waste is minimized.
• The safety cost of handling solvents. The PhasePrep II is a closed system. The exposure to spilled solvents, broken glassware and harmful solvent vapors is reduced.
• The cost of loosing laboratory integrity. This is the highest cost of all. What price can be put on mis-identifying a peak in a chromatogram because the solvent was not mixed accurately or a mislabeled solvent was used? The PhasePrep II prepares mixtures to an accuracy of a few hundreths of one percent or better—every time. A label is also printed to document the preparation. This minimizes the cost of re-works, non-conformance investigations and the costly delays that could result in not shipping finished product.